Chloroquine lung cancer

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  • Huh) Read
  • FDA approved the drug in 2023 as an initial
  • PMID: 32565933 PMCID: PMC7285842 DOI: 10
  • Acta Pharmacol Sin
  • Introduction
  • Cell apoptosis was detected by flow cytometry and western blot
  • 6 million cells provided sufficient power to make predictions using artificial intelligence

    Despite treatments such as surgery, radiation therapy and chemotherapy, only

    7 Lung cancer is

    Chloroquine is a potent blocker of autophagy and has been demonstrated in a lab setting to dramatically enhance tumor response to radiotherapy, chemotherapy and even anti-hormonal therapy

    The Cell Counting Kit 8 (CCK8) assay was used to determine the EPI IC 50 in A549 cells treated for 72 h

    Cancer cells are thought to use autophagy as a source of energy in the unfavorable metastatic environment, and a number of clinical trials are now revealing the promising role of

    The most common type of lung cancer is NSCLC, accounting for approximately 80% of all lung cancers

    We investigated the potential roles and mechanisms of hydroxychloroquine (HCQ) in combination with chemotherapy in lung cancer treatment

    Combinatorial treatment is a very useful method in cancer chemotherapy

    The hypothesis of adding these agents is to minimize cancer cell stress adaptive mechanisms and drug resistance

    2023 Jan 16 In vitro, the ACK1 inhibitors (AIM-100 and Dasatinib) appeared to trigger adaptive autophagy-like response to protect lung cancer cells from apoptosis and activated the AMPK/mTOR signaling pathway

    We hypothesized that the compounds could kill cancer cells effectively by inducing incomplete autophagy

    pmid:20630104

    As shown in Figure 3, very low levels of accumulation of F-pHPMA were observed in the

    Introduction

    These compounds were tested for growth inhibition against H460 and HCC827 human lung cancer and BxPC3 pancreatic

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  • Chloroquine lung cancer
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